Next-Generation Immunoassay Technology
Partnering with Global Life Science and Diagnostic companies to drive innovation and health outcomes
The biological testing marketplace is moving to develop assays that are simple to perform, but also more flexible and data-rich. Manufacturers also want reduced costs and an easy transition to a new technology format.
TGR BioSciences has developed and patented the next-generation of immunoassay technology, CaptSure™ that greatly reduces manufacturing costs, while delivering improvements in assay speed and broad application to different formats of immunoassay systems, such as ELISA, beads, and microfluidics.
CaptSure™ is composed of the CaptSure™ ligand, a monoclonal antibody specific for a non-biological peptide. This CaptSure™ peptide is covalently attached to the primary antibody of an immunoassay antibody pair. The CaptSure™ ligand is immobilised onto an assay surface, be it ELISA assay plate wells, beads, or microfluidic channels. The secondary assay antibody reports with standard assay technologies, such as enzymes, fluorphores, or Alpha beads, for example. The CaptSure™ system means that any surface that is CaptSure™ coated can bind any CaptSure™-tagged antibody. Thus, any well or bead can measure any target which is defined by the CaptSure™ tagged antibody presented to it. For example, any well of a 96 well assay plate can measure up to 96 different targets on a single plate.
This technology is utilised in TGR’s own assay systems (SureFire® Ultra™ and ELISA-One™) and has recently been licensed to three global assay manufacturers, and is available to other companies wanting to match these benefits for their own products in this competitive assay marketplace.
For Manufacturers of other immunoassay formats:
The CaptSure™ system has been validated by TGR in Alpha (PerkinElmer) assays, SureFire Ultra. Additionally, magnetic bead-based assays and other assay systems have also been developed by TGR. Each of these systems benefits from the attributes described above, including the reduction in manufacturing costs of the assay.