Jurkats are an IL-2 producing T lymphocyte cell line, commonly used to study T cell signaling. Established from the peripheral blood of a 14 year old boy with T cell leukemia, Jurkat cells are also useful for studying acute T cell leukemia. Jurkat cells are easy to culture, and grow rapidly. They express readily detectable levels of STAT1, STAT3 and STAT5, and so are useful for analysis of cytokine signaling. Jurkat cells are also useful for looking at stress-mediated pathways, including p38 MAPK, JNK signaling, and NF-kappaB signaling.
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